|
|
Time After Event |
Histopathologic Findings |
4-6 Hours |
Margination of polymorphonuclear leukocytes |
8-12Hours |
Diapedesis of polymorphonuclear leukocytes into the myocardial interstitial space |
1 day |
Hypereosinophilic fibers, nuclear pyknosis, coagulation necrosis, colliquative myocytolysis, edema, interstitial hemorrhage, contraction band necrosis, increase in neutrophilic infiltration |
2-3 days |
Marked polymorphonuclear infiltrate with extensive karyorrhexis, loss of myocyte nuclei |
4 days to 1 Week |
Macrophage infiltration, early granulation tissue with fibroblast response and capillary proliferation at the edges |
7 to 14 days |
Granulation tissue with hemosiderin-laden macrophages; variable amount of lymphocytes, rare plasma cells and eosinophils; polymorphonuclear leukocytes have disappeared |
2-8 weeks |
Granulation tissue matures with increased collagen deposition, which becomes prominent and more dense |
2 months |
Healed scar |