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Inflammatory diseases of the Aorta - Morphologic Patterns - II - Takayasu Arteritis Microscopy

Takayasu arteritis. The H&E stain shows very thick adventitia and intima layers with a somewhat thinned media. There is inflammatory infiltrate visible in the media and adventitia. The media shows collapse and partial destruction of the elastic lamellae. The intima shows an exuberant “neointima” with dense fibrous tissue as well as proteoglycan-rich connective tissue. The insets on the right panels show higher magnification with mononuclear inflammation and giant cells both on the H&E and the Movat stain.

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